HEROIN OVERDOSE DEATH: CONTRIBUTION OF DRUG-ASSOCIATED ENVIRONMENTAL CUES

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by , SCIENCE, NEW SERIES, V.216[4544], APRIL 23, 1982, PGS 436-437
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Heroin "overdose" death: contribution of drug-associated environmental cues. Siegel S, Hinson RE, Krank MD, McCully J. A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug by:   A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance.

Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced by: A model of ``overdose'' deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance.

Results of animal experiments performed to evaluate this model suggest that conditioned drug-anticipatory responses, in addition to pharmacological factors, affect heroin-induced mortality. Cited by: Heroin "Overdose" Death: Contribution of Drug-Associated Environmental Cues Abstract.

Amodelof"overdose" deathsamongheroin addicts is proposedwhich emphasizes recentfindings concerning the contribution ofdrug-associatedenviron-mentalcuestodrugtolerance.

Results ofanimalexperimentsperformedto evaluate. A Pavlovian conditioning model of tolerance emphasizes the contribution of an association between predrug cues and the systemic effects of the drug to tolerance.

In agreement with the model, results of a recent animal experiment indicate that the lethal effect of heroin, in drug-experienced rats, is influenced by the cues associated with its by: Heroin "Overdose" Death - Contribution of Drug-Associated Environmental Cues 1.

Universidade Estadual de Londrina Heroin “Overdose” Death: Contribuition of Drug-Associated Environmental Cues Siegel, S. et al Mayron Pereira Picolo Ribeiro Princípios da Análise do Comportamento Professor Carlos Eduardo Costa (CAÊ) Pós-Graduação em. Heroin "overdose" death: contribution of drug-associated environmental cues.

Science, (), pp. doi: /science Posted by Unknown at PM. Email This BlogThis. Share to Twitter Share to Facebook Share to Pinterest. Siegel S, Hinson RE, Krank MD, McCully J.

Heroin “overdose” death: Contribution of drug-associated environmental cues. Science. ; – Sokolowska M, Siegel S, Kim JA. Intraadministration associations: conditional hyperalgesia elicited by morphine onset cues. J Exp Psychol Anim Behav Process.

; –   Siegel S, Hinson RE, Krank MS, McCully J: Heroin "overdose" death: Contribution of drug-associated environmental cues. Science. In terms of survival time, they found that increased tolerance was extinguished, tt was concluded that drug- associated environmental cues contribute to the development of morphine tolerance.

However, both conclusions seem to be somewhat unconvincing. heroin injections were more likely to survive than rats with the identical pharmacological history receiving the final drug administration in an alternative environment. To further ascertain the role of drug-associated cues in heroin overdose, human overdose survivors were inter­ viewed.

METHOD Interviews were conducted with 10 former heroin. Title: Heroin ``Overdose'' Death: Contribution of Drug-Associated Environmental Cues Created Date: Z. [2] Shepard Siegel et al., “Heroin ‘Overdose’ Death: Contribution of Drug-Associated Environmental Cues,” Science (Ap ), accessed Octo [3] Arnold S.

Trebach, The Heroin Solution (Yale University Press, ). A number of other factors may contribute to heroin overdose death.

Allergy to morphine, absence of environmental cues associated with drug administration, genetic factors, contributing pathology, and drug interactions have all been proposed to influence ones risk of overdosing. Heroin overdose deaths in the Unites States more than tripled from toreaching alm per year.

Despite the use of the term “overdose,” many of these victims died after self-administering an amount of opiate that would not be expected to be fatal for these drug-experienced, and drug-tolerant, individuals. Various explanations of this overdose mystery have been.

A model of "overdose" deaths among heroin addicts is proposed which emphasizes recent findings concerning the contribution of drug-associated environmental cues to drug tolerance. If environmental cues were coordinating the brain to engage in specific reactions and develop a drug tolerance, then differences within the brain would be expected.

The neurons in the hippocampus and amygdala are postulated to participate in a mechanism of learning and memory necessary for processing and assigning value to drug-associated cues. Bulletin of the Psychonomic Society Pavlovian conditioning and heroin overdose: Reports by overdose victims SHEPARD SIEGEL 0 0 McMaster University, Hamilton, Ontario, Canada A Pavlovian conditioning model of tolerance emphasizes the contribution of an association between predrug cues and the systemic effects of the drug to tolerance.

Heroin overdose deaths in the Unites States more than tripled from toreaching alm per year. about the contribution of drug-associated cues to drug tolerance. Infamous for a high addiction potential and fatal respiratory depression in overdose, C. Alder Wright first synthesised this compound in trying to find a less addictive alternative to Morphine.

In recent years, it has often been sold cut with the extremely potent fentanyl, causing a spike in overdose deaths.

Description HEROIN OVERDOSE DEATH: CONTRIBUTION OF DRUG-ASSOCIATED ENVIRONMENTAL CUES PDF

Heroin "overdose" death: Contribution of drug-associated environmental cues. Science ~ Next: Computerized Performance Testing in Neurotoxicology: Why, What, How, and Whereto. Heroin overdose deaths in the Unites States more than tripled from toreaching alm per year. Despite the use of the term “overdose,” many of these victims died after self-administering an amount of opiate that would not be expected to be fatal for these drug-experienced, and drug-tolerant, individuals.

Intrigued by this finding, Siegel and co-workers () gathered data on heroin overdose deaths in humans. They found that victims of heroin overdose were typically occasional or weekend users, not daily users.

Often the fatal overdose occurred in unfamiliar environments. 24, articles and books. Periodicals Literature. Keyword Title Author Topic. Heroin "overdose" death: contribution of drug-associated environmental cues. Science (): Singer, G., M.

Wallace, and R.

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Hall. Effects of dopaminergic nucleus accumbens lesions on the acquisition of schedule induced self injection of. Siegel, S. Pavlovian conditioning and heroin overdoes: Reports by overdose victims. S., Hinson, R.E., Krank, M.D., & McCully, J. Heroin “overdose” death: The contribution of drug-associated environmental cues.

The environmental cues that originally did not elicit any response became conditioned or were learned to. Psychotropic drug consumption and other factors associated with heroin overdose - Drug and Alcohol Dependence In-text: (Gutiérrez-Cebollada et al., ).

Siegel et al., Heroin “overdose” death: contribution of drug-associated environmental cues. Science,Study Questions.

Details HEROIN OVERDOSE DEATH: CONTRIBUTION OF DRUG-ASSOCIATED ENVIRONMENTAL CUES FB2

Because many addicts die of apparent overdose at times when they have developed tolerance, what do the authors propose is actually happening. Describe the model of tolerance proposed by the authors. Siegel also found that tolerance would increase when the user was exposed to the usual drug associated environmental cues, but not when the user was exposed to different conditions.

could be the cause of the high incidence of opioid overdose among long-term dependent heroin users. ) Heroin “overdose” death: The contribution of.

Interviews with drug addicts who survived a heroin overdose similarly indicate a role for drug-associated en­ vironmental cues in opiate overdose (Siegel, ).

The majority of respondents reported that, on the occasion of the overdose, the drug was administered in the context of unusual environmental cues. Being a heroin addict is risky. In addition to other dangers inherent in being a criminal, death from overdose is a real possibility. Each year, 1% to 3% of heroin users die from overdose (Milloy, Kerr, Tyndall, Montaner, & Wood, ).Inthere were alm heroin overdose deaths in the United States (National Institute on Drug Abuse, ).

Siegel interviewed 10 heroin overdose survivors in an attempt to ascertain whether the overdoses occurred following novel pre-drug cues. For seven of the overdoses, the drug was administered in an environment not previously associated with drug use [ 5 ].

Siegel S, Hinson RE, Krank MS, McCully J: Heroin "overdose" death: Contribution of drug-associated environmental cues. SciencePosted by MorePheen at AM. Email This BlogThis! Share to Twitter Share to Facebook Share to Pinterest. 18 comments: Anonymous August 3, at PM.Who Recently Had Used Heroin and Were Admitted to a Hospital Emergency Room, Either for a Heroin A more thorough evaluation of the contribution of drug- Overdose or for Other Reasonsassociated cues to heroin overdose was reported by Gutie´r-rez-Cebollada, de la Torre, Ortun˜o, Garce´s, and Cam´ı Environment of heroin Reason for admission.